Integrated analysis of MIOX gene in prognosis of clear-cell renal cell carcinoma

Integrated analysis of MIOX gene in prognosis of clear-cell renal cell carcinoma

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Abstract Clear-cell renal cell carcinoma (ccRCC) is a highly aggressive malignancy that originates in the kidney.It often exhibits a limited response or can be refractory to a wide range of anti-cancer therapies, including tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors.Ferroptosis is a form of oxidative, iron-dependent cell death characterized by lipid peroxidation.Targeting ferroptosis may offer a promising alternative therapeutic strategy for cancer cells canon imageclass mf227dw that are resistant to existing treatments.The impact of ferroptosis-related genes on the prognosis of ccRCC patients is still not fully understood.

In this study, we identified 30 differentially expressed ferroptosis-related genes in ccRCC samples compared to normal tissues using data from The Cancer Genome Atlas (TCGA).Lasso regression analyses, along with Kaplan-Meier analysis, were conducted to identify genes associated with prognosis.Based on scRNA-seq and spatial transcriptome analysis, we identified specificity dorisvale station for sale of MIOX in ccRCC.Furthermore, MIOX demonstrated the highest significance, highlighting its independent prognostic value as a single gene in ccRCC.Our findings suggest that MIOX could serve as potential targets for therapeutic interventions in ccRCC.